By blocking of an enzyme that affects the cellular microenvironment it is possible to stop brain tumour cells from growing. This is shown in a new study published in the journal Molecular Cancer Therapeutics by researchers at Uppsala University in collaboration with researchers in Haifa, Israel and Brisbane, Australia.
In the latest issue of the journal Proceedings of the National Academy of Sciences (PNAS), a research group at Uppsala University presents a new, small-scale method that may become a smart shortcut for determining the “bioavailability” of a pharmaceutical drug within cells.
Specialized beta cells in the pancreas release the hormone insulin to control our blood glucose levels, and failure of this mechanism is central to the development of type-2 diabetes. How much and when insulin is released depends on a complex system of messenger molecules and proteins that is not well understood.
Time periods by calendar related to perceived stress are associated with the incidence rate of myocardial infarction (MI), says a new nationwide registry study of the Swedish population. Compared to control days, the daily incidence rate of MI was higher during the winter holidays, and on Mondays, whereas rates were lower during weekends and during the summer vacation in July.
Synchrotron scanning can produce high-quality 3D models of well-preserved food residues from fossil faeces. That's the result of a new study, by palaeontologists from Uppsala University and from ESRF Grenoble, which is presented in a new article in Scientific Reports.
One in five people dreams of publishing a novel. At the same time, there are no hard and fast criteria for determining whether a manuscript has the proper traits for publication by an established publisher. This creates a fundamental insecurity among both aspiring writers and publishers alike, according to a new dissertation from Uppsala University.
Why has the neoclassical Gustavian style become so prominent in the Swedish self-image? A new dissertation from Uppsala University shows how researchers in art history, along with museums, commercial enterprises and the monarchy, have contributed to preserving and conveying the Gustavian style.
A new study from Uppsala University in Sweden has indicated that the norm-conscious practices used by teachers at preschools termed “gender-neutral” are associated with reductions in children’s tendencies to make gender-stereotypical assumption. The practices are also associated with children’s increased interest in playing with unfamiliar peers of the opposite sex.
Achieving magnetic order in low-dimensional systems consisting of only one or two dimensions has been a research goal for some time. In a new study published in the journal Nature Communications, Uppsala researchers show that magnetic order can be created in a two-dimensional chessboard lattice consisting of organometallic molecules that are only one atomic layer thic
A drop of blood on filter paper, allowed to dry and stored for future diagnostic purposes – considerably easier than the present-day, resource-consuming method using frozen blood samples in plastic tubes. In a new study, Uppsala researchers measured 92 different proteins in dried samples and show the method has great potential to save resources, to the benefit of early diagnostics and treatment.
How did protein interactions arise, how have they developed? In a new study, researchers have looked at two proteins which began co-evolving between 400 and 600 million years ago. How did they work, and how have they changed over time? The findings, published in eLife, show how a combination of changes in the proteins’ properties created better conditions for the regulation of a cellular process.
With their measurements and samples, nearly 3,500 schoolchildren have assisted a research study on lakes and global warming, now published in the journal Scientific Reports. The results show that water temperatures generally remain low despite the air becoming warmer. This helps to curb the emission of greenhouse gases.
In a new study, researchers at Uppsala University have found evidence of a new principle for how epigenetic changes can occur. The principle is based on an enzyme, tryptase, that has epigenetic effects that cause cells to proliferate in an uncontrolled manner.
It is beneficial to systematise the exchange of information between parents, preschool and child care centres (CHCs) to increase the focus on young children with mental health problems. This is shown in a recently conducted study from Uppsala University, published in the journal PLOS One.
In a study published in the scientific journal Oncotarget, researchers from Uppsala University show how the protein EZH2 affects the development of multiple myeloma, and that inhibition of EZH2 could be used as a new strategy to treat the disease. The tumour form multiple myeloma is today incurable and it has been challenging to improve therapy.
Researchers at the Chinese Academy of Sciences in Beijing and Uppsala University, Uppsala, Sweden have put together all known information about the endangered Rufous-headed Robin. Very few observations have been made since it was first discovered in 1905. The researchers suggest that its distribution might be larger than previously thought.
Researchers at the Division of Solid-state Physics and the Division of Material Physics at Uppsala University have shown how the collective dynamics in a structure consisting of interacting magnetic nano-islands can be manipulated. Their findings are published in the scientific journal Scientific Reports
Antibody-based immunotherapy is a new promising method to treat cancer. Unfortunately, today’s treatments can result in adverse side effects. New findings from Uppsala University show an alternative way to administer the therapy, which has the same effect on the tumour but less impact other parts of the body.
Genetic differences in the FADS1 gene and varying ability to produce polyunsaturated fats like omega-3 and omega-6 determine the risk for many different diseases, such as inflammatory diseases and several types of cancer. Scientists at Uppsala University/SciLifeLab in Sweden have clarified this in detail and the work is published in the journal Nucleic Acids Research.
The mesoporous magnesium carbonate Upsalite® is shown to inhibit growth of Staphylococcus epidermidis, bacteria associated with acne and hospital acquired infections. That is the result of a study published in ACS Omega, by researchers at Uppsala University. The results open up for development of materials inhibiting bacterial growth without the use of antibiotics for e.g. dermal applications.