Scientists from Uppsala University, the Science for Life Laboratory (SciLifeLab) in Stockholm and Uppsala University Hospital have developed a new method of rapidly identifying which bacteria are causing an infection and determining whether they are resistant or sensitive to antibiotics. The findings are now being published in the Journal of Clinical Microbiology.
In a new study published in the scientific journal Oncotarget researchers from Uppsala University show that a therapeutic vaccine directed against tumor vessels can reduce tumor burden and suppress formation of spontaneous lung metastases in a mouse model for metastatic breast cancer.
If chronic lymphocytic leukemia patients with a good or poor prognosis could be identified already at the time of diagnosis, physicians would have better possibilities to adjust their therapeutic and follow-up strategies. Now researchers at Uppsala University have discovered a new correlation between specific molecular features of the disease and subgroups of patients with different prognosis.
Different types of glioma are usually diagnosed as separate diseases and have been considered to arise from different cell types in the brain. Now researchers at Uppsala University have shown that one and the same cell of origin can give rise to different types of glioma.
What does it mean to simulate the human brain? Why is it important to do so? And is it even possible to simulate the brain separately from the body it exists in? These questions are discussed in a new paper published in the scientific journal Neuron today.
A new Swedish study shows that adolescents who suffer from sleep disturbance or habitual short sleep duration are less likely to succeed academically compared to those who enjoy a good night’s sleep. The results have recently been published in the journal Sleep Medicine.
In a new study published in Nature Communications, research scientists from Uppsala University present for the first time a large-scale study of the significance of genetic, clinical and lifestyle factors for protein levels in the bloodstream. The results of the study show that genetics and lifestyle are determining factors for protein levels.
More than 80 percent of all drug candidates in the pharma R&D suffer from poor solubility and are therefore rejected early in the drug discovery process. Now Uppsala University researchers show that the new material Upsalite®, has great potential for development of new formulations of these rejected drugs.
In a new study published today in the journal Plos One, researchers at Uppsala University show that the harmful effect of smoking is aggravated if the person has high blood levels of PCB. This indicates that environmental contaminants interact with other risk factors for various diseases – a field the researchers claim is under-researched.
It is generally well known that men have an overall shorter life expectancy compared to women. A recent study, led by Uppsala University researchers, shows a correlation between a loss of the Y chromosome in blood cells and both a shorter life span and higher mortality from cancer in other organs.
When tumours grow, new blood vessels are formed that deliver oxygen and nutrients to the tumour cells. A research group at Uppsala University has discovered a new type of cell communication that results in suppressed blood vessel formation and delayed tumour growth.
A new study from Uppsala University, Sweden, shows that one night of sleep deprivation increases morning blood concentrations of NSE and S-100B in healthy young men. These molecules are typically found in the brain. Thus, their rise in blood after sleep loss may indicate that a lack of snoozing might be conducive to a loss of brain tissue. The findings are published in the journal SLEEP.
The fact that smoking means a considerable health risk is nowadays commonly accepted. New research findings from Uppsala University and Uppsala Clinical Research Center show that smoking alters several genes that can be associated with health problems for smokers, such as increased risk for cancer and diabetes.
Perfluorinated compounds are environmental toxins that are found in fire extinguishing foam and water-repellent textiles and, for example. In a new study, a research team led from Uppsala University has seen links between high levels of perfluorinated compounds in the blood and diabetes.
Retroviruses are important pathogens capable of crossing species barriers to infect new hosts, but knowledge of their evolutionary history is limited. By mapping endogenous retroviruses (ERVs), researchers at Uppsala University, Sweden, can now provide unique insights into the evolutionary relationships of retroviruses and their host species.
It was previously thought that the two test methods signalled the same type of asthma. But a new study, led by researchers at Uppsala University, Sweden, shows that the methods actually signal two different inflammatory processes. With the tests used in combination, the chances are probably greater for the patient to receive just the right treatment.
Why many diseases lead to calcifications in the brain is not known. New insights into the genetic causes of familial idiopathic basal ganglia calcification (FIBGC), also referred to as Fahr’s disease, pinpoint brain pericytes and a defective blood-brain barrier (BBB) as likely culprits in brain calcification. The findings were recently published in the journal Nature Genetics.
Researchers at Uppsala University and Yale University have identified a new mutation in adrenal gland tumor cells as a probable cause of hypertension. The findings were recently published in the journal Nature Genetics.
A new study reveals that all children with Crohn’s disease that were examined had a commonly occurring virus – an enterovirus – in their intestines. This link has previously not been shown for this chronic inflammatory intestinal disorder. The findings are being published today in the latest issue of the international journal Clinical and Translational Gastroenterology.
An international research team led by Swedish scientists has used a new method to investigate obesity and overweight as a cause of cardiovascular disease. Strong association have been found previously, but it has not been clear whether it was overweight as such that was the cause, or if the overweight was just a marker of another underlying cause.