Viruses have a very limited set of genes and therefore must use the cellular machineries of their hosts for most parts of their growth. A new study, led by scientists at Uppsala University, has discovered a specific host protein that many viruses use for their transport within the cell. The discovery opens up new possibilities to develop a broad spectrum anti-viral therapy.
Using self-sampling followed by HPV testing, more than twice as many women at risk of developing cervical cancer could be identified and offered preventive treatment. This is shown by researchers at Uppsala University in the first randomised study in the world comparing two ways of identifying cervical cancer, published today in the British Journal of Cancer.
In a new study, researchers from the universities of Uppsala and Lund show why insulin secretion is not working properly in patients suffering from type-2 diabetes. The report is published in the journal Cell Metabolism.
Researchers at Uppsala University and SLU have found a new way of accelerating wound healing. The technology and the mode of action method published in PNAS involves using lactic acid bacteria as vectors to produce and deliver a human chemokine on site in the wounds.
Thanks to advances in treatment options, the chances of surviving cancer are better than ever before. However, cancer incidence is increasing and new forms of therapy are expensive. As a result, resource management and priority setting face major challenges. How can we ensure equitable access to diagnosis and treatment? This topic is the focus of Uppsala Health Summit 2018, “Care for Cancer”.
Warding off the threats of future epidemics will be difficult without better cooperation and contingency plans that allow us to act before a crisis hits. This is one message in a new report summarising the discussions of the Uppsala Health Summit on the theme of Tackling Infectious Disease Threats: Prevent, Detect and Respond with a One Health Approach, which took place in October last year.
Over the last few decades, a wealth of evidence has accumulated to suggest that a lack of sleep is bad for mind and body. Working memory is important for keeping things in mind for briefer periods of time, which thereby facilitates reasoning and planning. A team of sleep scientists from Uppsala University now demonstrates that acute sleep loss impacts working memory differently in women and men.
A team of Swedish scientists have used national registries of more than 3.4 million Swedes aged 40 to 80 to study the association between dog ownership and cardiovascular health. Their study shows that dog owners had a lower risk of death due to cardiovascular disease or to other causes during the 12-year follow-up.
The effect of breastfeeding on the risk of developing asthma and allergy has been debated for a long time. In a recent study, Uppsala University researchers show that breastfeeding might in fact increase the risk of developing hay fever and eczema, while not having any clear effect on the risk of asthma. The results have been published in the Journal of Allergy and Clinical Immunology.
A research group at Uppsala University has found out how CRISPR-Cas9 - also known as ‘molecular scissors’ - can search the genome for a specific DNA sequence. The new research findings show how Cas9 can be improved to make the molecular scissors faster and more reliable. The study is being published in Science.
Infectious diseases are among the biggest threats to health in the world. Recurrent alarms about the risk of disease spread, epidemics and pandemics make the subject highly topical and evoke anxiety in many of us. In a report published today, Uppsala Health Summit lays the basis for discussion at the summit on 10–11 October on how to manage the threats.
The risk for developing obesity is influenced by our lifestyle as well as our genes. In a new study from Uppsala University, researchers show that our genetic risk for obesity is not static, but is influenced by our lifestyle. Results from the study have been published in the scientific journal PLOS Genetics.
An extensive exercise to map genetic variation in Sweden has found 33 million genetic variants, 10 million of which are novel. Large-scale DNA sequencing methods were used to analyse the whole genome of 1000 individuals from different parts of the country. The study was led by researchers at Uppsala University, who have published their findings in the European Journal of Human Genetics.
Researchers at Uppsala University have developed a new method for very rapidly determining whether infection-causing bacteria are resistant or susceptible to antibiotics. The findings have now been published in the US journal Proceedings of the National Academy of Sciences (PNAS).
In the latest issue of the journal Proceedings of the National Academy of Sciences (PNAS), a research group at Uppsala University presents a new, small-scale method that may become a smart shortcut for determining the “bioavailability” of a pharmaceutical drug within cells.
Specialized beta cells in the pancreas release the hormone insulin to control our blood glucose levels, and failure of this mechanism is central to the development of type-2 diabetes. How much and when insulin is released depends on a complex system of messenger molecules and proteins that is not well understood.
Time periods by calendar related to perceived stress are associated with the incidence rate of myocardial infarction (MI), says a new nationwide registry study of the Swedish population. Compared to control days, the daily incidence rate of MI was higher during the winter holidays, and on Mondays, whereas rates were lower during weekends and during the summer vacation in July.
Epigenetic changes are chemical modifications that turn our genes off or on. In a new study from Uppsala University, researchers show that tea consumption in women leads to epigenetic changes in genes that are known to interact with cancer and estrogen metabolism. The results are published in the journal Human Molecular Genetics.
Researchers from Uppsala University have studied betacells of type-2 diabetic donors, and find that a mislocalized calcium channel contributes to the failed insulin secretion associated with the disease.
How did protein interactions arise, how have they developed? In a new study, researchers have looked at two proteins which began co-evolving between 400 and 600 million years ago. How did they work, and how have they changed over time? The findings, published in eLife, show how a combination of changes in the proteins’ properties created better conditions for the regulation of a cellular process.