The majority of women who undergo surgery for suspected ovarian cancer do not have cancer. A novel blood test developed by researchers at Uppsala University and University of Gothenburg, now offers the possibility of more precise diagnostics. This could lead to a reduction in unnecessary surgery and to earlier detection and treatment for affected women. (Communications Biology).
One key question in evolutionary biology is how novel genes arise and develop. Swedish researchers now show how new genes and functions that are advantageous to bacteria can be selected from random DNA sequences. The results are presented in the scientific journal mBio.
Nearly ninety per cent of all cancer patient deaths are due to metastasis. A study from Uppsala University shows that a process that allows the cells to metastasise is aided by the synthesis of new ribosomes, the cell components in which proteins are produced. The results open the possibility for new treatment strategies for advanced cancers. The study is published in Nature Communications.
High levels of polychlorinated biphenyls (PCBs) in the blood are associated with premature death. This is shown by a cross-disciplinary study, based on 1,000 randomly selected 70-year-olds in Uppsala, that is published in the JAMA Network Open journal today.
Isolated human hepatocytes are essential tools in preclinical and clinical liver research, but cell quality is highly variable. Now, researchers from Uppsala University have devised a simple protocol that improves hepatocyte quality and enables cells from a wider quality spectrum to be used in standard and advanced cell culture. The findings are published in Archives of Toxicology.
Otherwise healthy men with advanced prostate cancer may benefit greatly from surgery, but many with this diagnosis have no need for it. These conclusions were reached by researchers after following a large group of Scandinavian men with prostate cancer for 29 years. The results are now published in The New England Journal of Medicine.
When deciding not to resuscitate patients in cardiac arrest, ethical issues arise. Nurses and physicians conflicting perspectives often cause frustration. In a new doctoral thesis from Uppsala University, Mona Pettersson examines clinical and ethical perspectives on “DNR orders” in cancer care.
Should researchers inform research participants, if they discover genetic disease risks in the participants? The value of complex genetic risk information for individuals is uncertain. In a PhD thesis from Uppsala University, Jennifer Viberg Johansson suggests that this uncertainty needs to be acknowledged by both geneticists and ethicists.
Why do some people comfortably walk between skyscrapers on a high-wire or raft the Niagara Falls in a wooden barrel whereas others freeze on the mere thought of climbing off escalators in a shopping mall? In a new study, scientists have found that a certain type of cells in the hippocampus play a key role.
To diagnose rheumatoid arthritis, antibodies to the amino acid citrulline are commonly measured. A new study from Uppsala University shows that a broad mix of different antibodies in the joints is the dominant factor that can be associated with severe inflammation and joint damage. These findings, published in Annals of the Rheumatic Diseases, may eventually lead to improved diagnostics.
The challenges of future cancer care are in focus when Uppsala Health Summit 2018 opens next week. The annual summit will be attended by important international actors from health organisations, academia, industry, civil society and policy organisations.
Uppsala University, Uppsala University Hospital and the European Infrastructure for Translational Medicine (EATRIS) have formed a collaboration with GlaxoSmithKline (GSK) to deliver a clinical and scientific expert network for the development and application of innovative imaging methods for inflammatory diseases.
In a new study, researchers at Uppsala University and other institutions have identified genetic material from the recently identified Alkhurma hemorrhagic fever virus in the tick species Hyalomma rufipes. The discovery was made after thousands of ticks were collected from migratory birds . The results indicate that birds could contribute to spreading the virus to new geographical areas.
Cellular lipids are more efficient than proteins in trapping most drugs and hence reducing the free intracellular drug concentration. This is shown by researchers at Uppsala University in an article published in Molecular Pharmaceutic.
A new study published in Nature Communications shows that infants who are later diagnosed with autism react more strongly to sudden changes in light. This finding provides support for the view that sensory processing plays an important role in the development of the disorder.
Dynamic interactions between the nervous system, hormones and the immune system are normally on-going but in diabetes the balance is disturbed. The two studies published in EBioMedicine by an international research team from Uppsala University highlight the importance of the neurotransmitter gamma-aminobutyric acid (GABA) in both Type 1 and Type 2 diabetes.
Viruses have a very limited set of genes and therefore must use the cellular machineries of their hosts for most parts of their growth. A new study, led by scientists at Uppsala University, has discovered a specific host protein that many viruses use for their transport within the cell. The discovery opens up new possibilities to develop a broad spectrum anti-viral therapy.
Using self-sampling followed by HPV testing, more than twice as many women at risk of developing cervical cancer could be identified and offered preventive treatment. This is shown by researchers at Uppsala University in the first randomised study in the world comparing two ways of identifying cervical cancer, published today in the British Journal of Cancer.
In a new study, researchers from the universities of Uppsala and Lund show why insulin secretion is not working properly in patients suffering from type-2 diabetes. The report is published in the journal Cell Metabolism.
Researchers at Uppsala University and SLU have found a new way of accelerating wound healing. The technology and the mode of action method published in PNAS involves using lactic acid bacteria as vectors to produce and deliver a human chemokine on site in the wounds.