Researchers at Uppsala University and Uppsala University Hospital have developed a new method to measure levels of the medication hydroxychloroquine in patients with the rheumatic disease systemic lupus erythematosus (SLE). The analysis method may also be useful in other areas, such as in the treatment of COVID-19. The study is being published in Arthritis Research and Therapy.
Researchers at Uppsala University and Uppsala University Hospital have developed a new method to measure levels of the medication hydroxychloroquine in patients with the rheumatic disease systemic lupus erythematosus (SLE). The analysis method may also be useful in other areas, such as in the treatment of COVID-19. The study is being published in Arthritis Research and Therapy.
Patients taking part in clinical trials do not receive better treatment than other patients. This is the conclusion of a new study led from Uppsala University and published in peer-reviewed journal BMC Cancer, which confirms the results of an earlier study from 2004.
Artificial intelligence (AI) may be an aid to interpreting ECG results, helping healthcare staff to diagnose diseases that affect the heart. Researchers at Uppsala University and heart specialists in Brazil have developed an AI that automatically diagnoses atrial fibrillation and five other common ECG abnormalities just as well as a cardiologist.
In an international collaboration, researchers from Uppsala University have mapped the lymph node lymphatic vessels in mice and humans down to the level of individual cells. The results may eventually help scientists to discover new methods for strengthening the immune system against viruses and cancer. Their work has been published in the journal Frontiers of Cardiovascular Research.
Patients with type 2 diabetes secrete not only too little insulin but also too much glucagon, which contributes to poor blood glucose control. A new study from Uppsala University suggests that this is because the glucagon-secreting α-cells have become resistant to insulin.
What does it actually look like deep inside our ears? This is has been very difficult to study as the inner ear is protected by the hardest bone in the body. But together with Canadian colleagues, researchers from Uppsala University have now used synchrotron X-rays to map the blood vessels of the inner ear three-dimensionally.
Cancer cells grow and divide in an uncontrolled manner. A new study from Uppsala University now shows how alterations in a cell’s degradation hubs, called lysosomes, can cause abnormal cell growth. The results are published today in the scientific journal Nature Communications.
Could the ability of cancer cells to quickly alter their genome be used as a weapon against malignant tumours? Researchers at Uppsala University have succeeded in developing a substance that has demonstrated promising results in experiments on both animal models and human cancer cells. The study is published in the journal Nature Communications.
The balance between the neurotransmitters serotonin and dopamine may affect whether a person develops social anxiety disorder. Previous research has mainly focused on either the serotonin or the dopamine system individually. Now researchers at Uppsala University have demonstrated the existence of a previously unknown link between the two. The results are published in Molecular Psychiatry.
A preliminary study by researchers at Uppsala University has found that when young, healthy men were deprived of just one night of sleep, they had higher levels of tau – a biomarker for Alzheimer’s disease – in their blood than when they had a full, uninterrupted night of rest. The study is published in the medical journal Neurology.
Using a computer algorithm, scientists at Uppsala University have identified a promising new treatment for neuroblastoma. This form of cancer in children, which occurs in specialised nerve cells in the sympathetic nervous system, may be life-threatening.
How variable are gene transcripts and proteins, the molecules of life, across the tissues and organs of the human body? Furthermore, how variable are they within the same tissue type from different people? These questions are the focus of a new study led by researchers from Uppsala University, which is published in NAR Genomics and Bioinformatics.
In a new study, researchers at Uppsala University have identified a previously unknown mechanism that regulates release of insulin, a hormone that lowers blood glucose levels, from the β-cells (beta cells) of the pancreas. This mechanism is disrupted in type 2 diabetes. The scientists hope this finding will be used to develop new treatments against the disease.
Patients who attend ‘Heart School’, as almost every patient is invited to do after a first heart attack, live longer than non-participating patients. This is shown in a new study, by researchers at Uppsala University, published in the European Journal of Preventive Cardiology.
A comprehensive study from Uppsala University, with over 325,000 participants, shows that deep belly fat is a major contributing risk factor for developing diabetes and cardiovascular disease. The study also shows that deep belly fat is a larger risk factor in women compared to men.
Reference reagents are important in diagnostics and care of patients with systemic lupus erythematosus (SLE). An international team of researchers now presents a WHO autoantibody reference reagent that will help to align autoantibody analyses and thus to optimise diagnosis and treatment to patients irrespective of where they live. The findings are published in Annals of the Rheumatic Diseases.
There is a growing demand for diagnostic markers for early disease detection and prognosis. Exosomes are potential biomarkers for cancer progression and neurodegenerative disease but it can be difficult to identify what tissue a specific exosome comes from. Researchers have solved this problem by developing a method that maps surface protein complements on large numbers of individual exosomes.
In a new study from SciLifeLab at Uppsala University, researchers have found a total of 141 regions (genes) in our genetic material that largely explain the genetic risk underlying asthma, hay fever and eczema. As many as 41 of the genes identified have not previously been linked to an elevated risk for these diseases. The results are published in the scientific journal Human Molecular Genetics.
Bacterial ribosomes need a single-stranded ribosome binding site (RBS) to initiate protein synthesis, whereas stable RNA structure blocks initiation. Paradoxically, structured mRNAs can nevertheless be efficiently translated. Researchers at Uppsala University have now elucidated the anatomy of a "standby" site and its requirements, to overcome RNA structure problems for translation.