The frequency of mast cell progenitors in the blood circulation is higher in asthma patients during the birch pollen season than outside of it. This has been demonstrated in a new study by Uppsala University, published in the scholarly journal Allergy.
Researchers at Uppsala University, Stockholm University and KTH have managed to create a new spatial omics method. By combining two complex techniques that are usually used separately – mass spectrometry imaging (MSI) and spatially resolved transcriptomics (SRT) – they have taken an important step in research on biological tissues. The study is published in the Nature Biotechnology.
In a major Swedish study, researchers have discovered a link between the levels of certain bacteria living in the gut and coronary atherosclerotic plaques. Such atherosclerotic plaques constitute a major cause of heart attacks. The study was led by researchers at Uppsala University and Lund University and the findings have now been published in the scientific journal Circulation.
Many studies have linked obesity to an increased risk of cancer, but most have not differentiated the risks between men and women. In a new study published in Cancer Cell, researchers from Uppsala University takes a closer look at this connection.
A new study has discovered that the pro-viral host protein ZC3H11A has a critical role to maintain embryo viability during early development. The study has uncovered a previously unknown function of ZC3H11A in the intricate process of embryonic growth and highlights its impact on development. The study is led by Uppsala University and INRAE/Université Paris-Saclay, now published in journal PNAS.
In a new study, researchers at Uppsala University have investigated how junk food affects sleep. Healthy participants consumed an unhealthier as well as a healthier diet in a randomised order. After the unhealthier diet, the quality of the participants’ deep sleep had deteriorated, compared with those who had followed the healthier diet. The results have been published in the journal Obesity.
A major international research project, jointly led by Prof Kerstin Lindblad-Toh at Uppsala University and Broad Institute has surveyed and analysed the genomes of 240 different mammals. The results, now published in 11 articles in the journal Science, show how the genomes of humans and other mammals have developed over the course of evolution.
Patients treated with blood pressure-lowering drugs can experience much greater improvements from a change of medication than from doubling the dose of their current medication. This is shown by a new study from Uppsala University, published in the Journal of the American Medical Association. In this study, 280 patients tested four different blood pressure-lowering drugs over the course of a year.
Overweight and obesity among four-year-olds increased during the COVID-19 pandemic, according to a new study by Uppsala University involving over 200,000 children in Sweden. The number of children with obesity increased by some 30 percent, and there are large regional differences. The study was published in the journal Acta Paediatrica.
The use of broad-spectrum antibiotics increased drastically in intensive care at the beginning of the Covid-19 pandemic. At first, this helped patients and seemed to prevent the growth of most bacteria. However, it also contributed to a sharp growth in enterococci, an antibiotic-tolerant group of bacteria, which rendered the treatment of urinary tract infections more difficult.
Thanks to a new prognostic method for detecting cancers including cancer of the large intestine, doctors could provide clearer disease prognoses and predict which patients will respond best to immunotherapy. The method consists of a combination of two types of immune cells that characterise certain forms of cancer. This has been shown in a new study published in the journal eBioMedicine.
The earlier infants begin to taste small samples of solid food, the earlier they eat more food and stop breastfeeding. This is shown in a new study from Uppsala University and Sophiahemmet University, in which the mothers of 1,251 infants from all over Sweden participated. Almost half of the infants received tastings at the age of four months.
Bacterial perseverance is a new phenomenon that helps explain how bacteria adapt to survive antibiotic treatments. A group of researchers at Uppsala University have studied how individual bacteria react when exposed to different antibiotics. The result underlines the importance of adhering strictly to antibiotic prescriptions.
Using new gene mapping methods, researchers have found connections between atopic dermatitis in dogs and several regions of the genome. Some genes identified coincide with genes linked to similar problems in humans. The filaggrin gene region, for example, which is regarded as the most powerful risk factor for atopic eczema in humans, has now also been linked to this disease in Labrador retrievers.
An team of surgeons and scientists from, among others, Uppsala University has confirmed secure surgical access to the central core of the human cochlea. The research, published in Scientific Reports, is critical to the first in-human trials of new cell, gene and drug therapies for the inner ear, and will assist with treatment for improving hearing loss and deafness over the long-term.
Neurochemical changes in the brain differ among patients with social anxiety treated using both SSRIs and CBT, compared to those treated using only CBT. While the combined treatment involving the medicine blocked the serotonin transporters, availability of such transporters increased in patients who only received CBT. In a double-blind positron emission tomography (PET) study, 24 participants.
Using state of the art techniques, researchers from Uppsala University have shown that the metabolism in patients with type 2 diabetes and prediabetes was much more disturbed than previously known, and that it varied between organs and with the severity of the disease. The study, a collaboration with Copenhagen University and AstraZeneca, among others, has been published in Cell Reports Medicine.
A new study from Uppsala University shows that using a weighted blanket at bedtime increases melatonin in young adults. This hormone increases in response to darkness, and some evidence suggests that it promotes sleep. The findings are published in the Journal of Sleep Research.
There are strong links between bacteria living in the gut and the levels of small molecules in the blood known as metabolites. Such is the finding of a new study (Uppsala University/Lund University). The study is based on analyses of both fecal and blood samples from 8,583 participants in the Swedish CArdioPulmonary bioImage Study (SCAPIS).
In the condition known as cerebral cavernoma, lesions arise in a cluster of blood vessels in the brain. In a new study from Uppsala University, researchers show that blood coagulation and blood clot formation are very relevant for the disease and that antithrombotic therapy may be beneficial for cavernoma patients.
