A new study from Uppsala University shows that whole-genome sequencing increases the precision of genetic studies, which in turn can improve our understanding of how to use biomarkers to discover disease. The results are published in the scientific journal Scientific Reports.
In a new study, researchers at Uppsala University compared the carbon footprint of two kinds of inhaler used for treating asthma and chronic obstructive pulmonary disease: dry powder inhalers and sprays containing propellants. The results show that treatment with spray inhalers has a carbon footprint 20 times greater than that of using dry powder inhalers.
In a new study, researchers at Uppsala University have identified a previously unknown mechanism that regulates release of insulin, a hormone that lowers blood glucose levels, from the β-cells (beta cells) of the pancreas. This mechanism is disrupted in type 2 diabetes. The scientists hope this finding will be used to develop new treatments against the disease.
Patients who attend ‘Heart School’, as almost every patient is invited to do after a first heart attack, live longer than non-participating patients. This is shown in a new study, by researchers at Uppsala University, published in the European Journal of Preventive Cardiology.
A comprehensive study from Uppsala University, with over 325,000 participants, shows that deep belly fat is a major contributing risk factor for developing diabetes and cardiovascular disease. The study also shows that deep belly fat is a larger risk factor in women compared to men.
Reference reagents are important in diagnostics and care of patients with systemic lupus erythematosus (SLE). An international team of researchers now presents a WHO autoantibody reference reagent that will help to align autoantibody analyses and thus to optimise diagnosis and treatment to patients irrespective of where they live. The findings are published in Annals of the Rheumatic Diseases.
There is a growing demand for diagnostic markers for early disease detection and prognosis. Exosomes are potential biomarkers for cancer progression and neurodegenerative disease but it can be difficult to identify what tissue a specific exosome comes from. Researchers have solved this problem by developing a method that maps surface protein complements on large numbers of individual exosomes.
Long-lived mushrooms that grow in ‘fairy rings’ accumulate surprisingly few mutations over time. This finding indicates that their protection against harmful mutations is well developed. The results, to be published in the esteemed journal Current Biology, are interesting in terms of both medicine and evolutionary biology.
In a new study from SciLifeLab at Uppsala University, researchers have found a total of 141 regions (genes) in our genetic material that largely explain the genetic risk underlying asthma, hay fever and eczema. As many as 41 of the genes identified have not previously been linked to an elevated risk for these diseases. The results are published in the scientific journal Human Molecular Genetics.
One key question in evolutionary biology is how novel genes arise and develop. Swedish researchers now show how new genes and functions that are advantageous to bacteria can be selected from random DNA sequences. The results are presented in the scientific journal mBio.
Nearly ninety per cent of all cancer patient deaths are due to metastasis. A study from Uppsala University shows that a process that allows the cells to metastasise is aided by the synthesis of new ribosomes, the cell components in which proteins are produced. The results open the possibility for new treatment strategies for advanced cancers. The study is published in Nature Communications.
High levels of polychlorinated biphenyls (PCBs) in the blood are associated with premature death. This is shown by a cross-disciplinary study, based on 1,000 randomly selected 70-year-olds in Uppsala, that is published in the JAMA Network Open journal today.
Many diabetes patients do not only have problems with their insulin, but also with the release of the hormone glucagon. Researchers at Uppsala University have now discovered a regulation mechanism which could provide an opportunity to improve blood glucose control in these patients. The research is published in the journal Diebetologia.
When antibiotics are used to treat bacteria susceptible to them, the treatment usually works. Nevertheless, the antibiotic chosen is sometimes ineffective. One of the reasons for this is heteroresistance, a phenomenon explored in depth by Uppsala and Emory University researchers in a new study.
A study from Uppsala University has found that whether you store your fat around the trunk or in other parts of your body is highly influenced by genetic factors and that this effect is present predominantly in women and to a much lower extent in men. In the study, published in Nature Communications, the researchers measured how fat was distributed in nearly 360,000 voluntary participants.
Isolated human hepatocytes are essential tools in preclinical and clinical liver research, but cell quality is highly variable. Now, researchers from Uppsala University have devised a simple protocol that improves hepatocyte quality and enables cells from a wider quality spectrum to be used in standard and advanced cell culture. The findings are published in Archives of Toxicology.
Otherwise healthy men with advanced prostate cancer may benefit greatly from surgery, but many with this diagnosis have no need for it. These conclusions were reached by researchers after following a large group of Scandinavian men with prostate cancer for 29 years. The results are now published in The New England Journal of Medicine.
When deciding not to resuscitate patients in cardiac arrest, ethical issues arise. Nurses and physicians conflicting perspectives often cause frustration. In a new doctoral thesis from Uppsala University, Mona Pettersson examines clinical and ethical perspectives on “DNR orders” in cancer care.
Retroviruses have colonised vertebrate hosts for millions of years by inserting their genes into host genomes, enabling their inheritance through generations as endogenous retroviruses (ERVs). Researchers from Uppsala University now provide new knowledge about the long-term associations of retroviruses and their hosts by studying ERV variation and segregation in wild and domestic rabbits.
Should researchers inform research participants, if they discover genetic disease risks in the participants? The value of complex genetic risk information for individuals is uncertain. In a PhD thesis from Uppsala University, Jennifer Viberg Johansson suggests that this uncertainty needs to be acknowledged by both geneticists and ethicists.