A research group at Uppsala University has found out how CRISPR-Cas9 - also known as ‘molecular scissors’ - can search the genome for a specific DNA sequence. The new research findings show how Cas9 can be improved to make the molecular scissors faster and more reliable. The study is being published in Science.
Previous research has shown that there is a connection between epigenetic changes and some of our common illnesses. But what does this connection mean? A new study shows that external factors, such as lifestyle aspects, often affect both the epigenetic pattern and cause the disease. The results have been published in PLOS Genetics.
A new species of extinct sea monster from the Early Jurassic has been identified by a team of German and Swedish researchers. The fossilized bones were found in a clay pit near the city of Bielefeld in Germany. The findings will be published in the journal Alcheringa.
Preschool children in joint physical custody have less psychological symptoms than those who live mostly or only with one parent after a separation. That shows a new Swedish study of 3,656 children, done by researchers from Uppsala University, Karolinska Institutet and the research institute CHESS, which is now published in Acta Pædiatrica.
Infectious diseases are among the biggest threats to health in the world. Recurrent alarms about the risk of disease spread, epidemics and pandemics make the subject highly topical and evoke anxiety in many of us. In a report published today, Uppsala Health Summit lays the basis for discussion at the summit on 10–11 October on how to manage the threats.
The risk for developing obesity is influenced by our lifestyle as well as our genes. In a new study from Uppsala University, researchers show that our genetic risk for obesity is not static, but is influenced by our lifestyle. Results from the study have been published in the scientific journal PLOS Genetics.
Newly discovered human-like footprints from Crete may put the established narrative of early human evolution to the test. The footprints are approximately 5.7 million years old and were made at a time when previous research puts our ancestors in Africa – with ape-like feet.
A previously unrecognized 132 million-year-old fossilized sea monster from northern Germany has been identified by an international team of researchers. Findings published in the Journal of Vertebrate Paleontology.
An extensive exercise to map genetic variation in Sweden has found 33 million genetic variants, 10 million of which are novel. Large-scale DNA sequencing methods were used to analyse the whole genome of 1000 individuals from different parts of the country. The study was led by researchers at Uppsala University, who have published their findings in the European Journal of Human Genetics.
Researchers at Uppsala University have developed a new method for very rapidly determining whether infection-causing bacteria are resistant or susceptible to antibiotics. The findings have now been published in the US journal Proceedings of the National Academy of Sciences (PNAS).
"Which factors increase the chance of aging with well-maintained functions?" Older men who never smoked, avoided obesity and had held a healthy Mediterranean-inspired diet have good chances of maintaining their independence at a very high age.
By blocking of an enzyme that affects the cellular microenvironment it is possible to stop brain tumour cells from growing. This is shown in a new study published in the journal Molecular Cancer Therapeutics by researchers at Uppsala University in collaboration with researchers in Haifa, Israel and Brisbane, Australia.
In the latest issue of the journal Proceedings of the National Academy of Sciences (PNAS), a research group at Uppsala University presents a new, small-scale method that may become a smart shortcut for determining the “bioavailability” of a pharmaceutical drug within cells.
Specialized beta cells in the pancreas release the hormone insulin to control our blood glucose levels, and failure of this mechanism is central to the development of type-2 diabetes. How much and when insulin is released depends on a complex system of messenger molecules and proteins that is not well understood.
Time periods by calendar related to perceived stress are associated with the incidence rate of myocardial infarction (MI), says a new nationwide registry study of the Swedish population. Compared to control days, the daily incidence rate of MI was higher during the winter holidays, and on Mondays, whereas rates were lower during weekends and during the summer vacation in July.
Some insulin is still produced in almost half of the patients that have had type 1 diabetes for more than ten years. The study conducted by researchers at Uppsala University in Sweden has now been published online by the medical journal Diabetes Care.
Juvenile birds discriminate and selectively learn their own species’ songs even when primarily exposed to the songs of other species, but the underlying mechanism has remained unknown. A new study, by researchers at Uppsala University, shows that song discrimination arises due to genetic differences between species, rather than early learning or other mechanisms.
Synchrotron scanning can produce high-quality 3D models of well-preserved food residues from fossil faeces. That's the result of a new study, by palaeontologists from Uppsala University and from ESRF Grenoble, which is presented in a new article in Scientific Reports.
One in five people dreams of publishing a novel. At the same time, there are no hard and fast criteria for determining whether a manuscript has the proper traits for publication by an established publisher. This creates a fundamental insecurity among both aspiring writers and publishers alike, according to a new dissertation from Uppsala University.
Why has the neoclassical Gustavian style become so prominent in the Swedish self-image? A new dissertation from Uppsala University shows how researchers in art history, along with museums, commercial enterprises and the monarchy, have contributed to preserving and conveying the Gustavian style.