A large international consortium led by scientists at Uppsala University and the Broad Institute of MIT and Harvard has sequenced the genome of 130 mammals and analysed the data together with 110 existing genomes to allow scientist to identify which are the important positions in the DNA. The study is published in Nature.
How can stress in animals be measured? Scientists from Uppsala University and elsewhere have now found that what are known as epigenetic biomarkers could be used to detect long-term exposure to stress in commercially raised chickens. This may, in time, lead to improved conditions in animal rearing. The study has been published in the journal Frontiers in Genetics.
The Scandinavian wolf originally came from Finland and Russia, and unlike many other European wolf populations its genetic constitution is virtually free from dog admixture. In addition, individuals have migrated into and out of Scandinavia. These findings have emerged from new research at Uppsala University in which genetic material from more than 200 wolves was analysed.
When and how did the first animals appear? Science has long sought an answer. Uppsala University researchers and colleagues in Denmark have now jointly found, in Greenland, embryo-like microfossils up to 570 million years old, revealing that organisms of this type were dispersed throughout the world. The study is published in Communications Biology.
In the condition known as cavernoma, lesions arise in a cluster of blood vessels in the brain, spinal cord or retina. Researchers from Uppsala University can now show, at molecular level, that these changes originate in vein cells. This new knowledge of the condition creates potential for developing better therapies for patients. The study has been published in the journal eLife.
How can new life forms that we cannot see be discovered? Using a novel method based on looking for DNA in soil samples, researchers at Uppsala University have revealed the existence of two hitherto unknown, but very common fungus species. They are thought to perform a key function in the ecosystem, but their exact role remains to be clarified. The study is published in the journal IMA Fungus.
In Alzheimer’s disease, a protein (peptide) forms clumps in the brain and causes sufferers to lose their memory. In a recently published article, a research group at Uppsala University described a new treatment method that increases the body’s own degradation of the building blocks that lead to these protein clumps.
Big tidal ranges some 400 million years ago may have initiated the evolution of bony fish and land vertebrates. This theory is now supported by researchers in the UK and at Uppsala University who, for the first time, have used established mathematical models to simulate tides on Earth during this period. The study has been published in Proceedings of the Royal Society A.
In situ sequencing enables gene activity inside body tissues to be depicted in microscope images. To facilitate interpretation of the vast quantities of information generated, Uppsala University researchers have now developed an entirely new method of image analysis. Based on algorithms used in artificial intelligence, the method was originally devised to enhance understanding of social networks.
A team of scientists led from Uppsala University have described the earliest known example of dentary bone with two rows of cusps on molars and double-rooted teeth. The new findings offer insight into mammal tooth evolution, particularly the development of double-rooted teeth. The results are published in the scientific journal PNAS.
Researchers at Uppsala University have found that an effective way of treating the coronavirus behind the 2003 SARS epidemic also works on the closely related SARS-CoV-2 virus, the culprit in the ongoing COVID-19 pandemic. The substance concerned is nitric oxide (NO), a compound with antiviral properties that is produced by the body itself. The study is published in the journal Redox Biology.
Researchers at Uppsala University have developed a new method to determine – rapidly, easily and cheaply – how effective two antibiotics combined can be in stopping bacterial growth. The new method is simple for laboratories to use and can provide greater scope for customising treatment of bacterial infections. The study is published in PLOS Biology.
The European research initiative BATTERY 2030+ is now getting going. The ambition is to make Europe a world-leader in the development and production of the batteries of the future. These batteries need to store more energy, have a longer life, and be safer and more environmentally friendly than today’s batteries in order to facilitate the transition to a more climate-neutral society.
The evolution of sex chromosomes is of crucial importance in biology as it stabilises the mechanism underlying sex determination and usually results in an equal sex ratio. An international team of scientists, led by researchers from Uppsala University, now reports that they have been able to reconstruct the birth of a male sex chromosome in the Atlantic herring.
You might need a microscope to witness the next agricultural revolution. New research, published in the journal Science Advances, demonstrates how microfluidic technologies can be used to identify, isolate and propagate specific single photosynthetically active cells for fundamental industry applications and improved ecosystem understanding.
Why so many COVID-19 patients get blood clots (thrombosis) remains uncertain. But scientists at Uppsala University and the University Hospital have now identified a mechanism they believe to be implicated. A particular protein triggers a part of our immune system that can boost the blood’s tendency to coagulate and form clots. The study is now published in Thrombosis and Haemostasis.
In 19th-century Sweden, workers’ wages rose faster than in other European countries. By 1900, they were among the highest in Europe, and the steepest rise of all had been for those who earned least. This is shown by new research at Uppsala University: a study published in The Journal of Economic History.
Researchers have discovered a new group of Chlamydiae, Anoxychlamydiales, living under the ocean floor without oxygen. These have genes that allow them to survive without oxygen while making hydrogen gas. The researchers found that our single-cell ancestors ‘caught’ these hydrogen-producing genes from ancient Chlamydiae up to two-billion years ago – The results are published in Science Advances.
Researchers at Uppsala University have described the presence, throughout the human body, of the enzyme ACE2. This is thought to be the key protein used by the SARS-CoV-2 virus for host cell entry and development of the disease COVID-19. In contrast to previous studies, the study shows that no or very little ACE2 protein is present in the normal respiratory system.
In a new study, a research group at Uppsala University explain their outstanding success in harvesting “hot electron holes”. The results of their work can be used to improve solar cells, photochemical reactions and photosensors. The scientific article is published in Nature Materials.