Researchers from Uppsala University have developed a method that helps immune cells exit from blood vessels into the tumour and kill cancer cells. The aim is to improve treatment of aggressive brain tumours. The study has been published in the journal Cancer Cell.
Using serial femtosecond crystallography performed with the XFEL technique, scientists have been able to see the crucial final step in the reaction cycle of Photosystem II, and managed to obtain more information on the interaction between Photosystem II and the Mn/Ca cluster. "Such a development is important for scaling up hydrogen production from water by sunlight or renewable electricity."
One strategy that viruses use to take over a host cell is to mimic small parts of the cell's proteins called motifs. In a new study coordinated from Uppsala University, researchers have used a new method and doubled the available information on how viruses mimic human binding motifs. The results suggest new targets for the development of antiviral inhibitors.
A major international research project, jointly led by Prof Kerstin Lindblad-Toh at Uppsala University and Broad Institute has surveyed and analysed the genomes of 240 different mammals. The results, now published in 11 articles in the journal Science, show how the genomes of humans and other mammals have developed over the course of evolution.
A new study by researchers at Uppsala University and Uppsala University Hospital shows that men who have a neurodevelopmental disorder, such as autism and ADHD, also have a slightly increased risk of testicular cancer, or seminoma. This is the first study to show such a link, with the results to be published in the British Journal of Cancer.
A new study led by researchers from Uppsala University shows a clear link between economic inequality and mortality during severe flood disasters. Countries with an uneven distribution of income had many times higher mortality rates compared to countries with more evenly distributed income levels. The results are published in the scientific journal Nature Sustainability.
Patients treated with blood pressure-lowering drugs can experience much greater improvements from a change of medication than from doubling the dose of their current medication. This is shown by a new study from Uppsala University, published in the Journal of the American Medical Association. In this study, 280 patients tested four different blood pressure-lowering drugs over the course of a year.
Rich elites with large swimming pools and well-maintained lawns are leaving poorer communities without basic access to water in cities across the world. New research, led by Uppsala University, published in Nature Sustainability has found social inequalities are driving urban water crises more than environmental factors, such as climate change or the growth of urban populations.
When the human remains found on board the warship Vasa were investigated, it was determined that the skeleton designated G was a man. New research now shows that the skeleton is actually from a woman. "It is very difficult to extract DNA from bone which has been on the bottom of the sea for 333 years, but not impossible”, says Marie Allen, Professor at Uppsala University.
The sharp increase in heatwaves in southern Europe in recent years is not only due to the greenhouse effect. Climate change has made a particular type of atmospheric circulation pattern more common, and this has contributed to extreme weather and been the underlying cause of nine out of ten heat-related deaths. This is according to a new study by researchers from Uppsala University and CNRS.
A new study from researchers at Uppsala University and Karolinska Institutet shows that children who go on to develop symptoms of autism have different activity in their brain's visual cortex from as early as five months when looking at certain types of movement. This finding may indicate that autistic people perceive their surroundings in a different way even from a very young age.
Churches are preserved by an antiquarian system that risks killing them instead of keeping them alive. The Swedish State and the Church of Sweden therefore need to define new joint visions and goals to enable the ecclesiastical cultural heritage to be used and developed. This is shown by historian of art Henrik Lindblad in a new doctoral thesis from Uppsala University.
Scientists from Uppsala University have used cryo-electron microscopy to reveal details of the protein synthesis mechanism in the parasite Giardia intestinalis, which causes diarrhoeal disease. The new insights could be valuable for screening specific drugs against Giardia and other protozoan parasites.
For nearly 190 years, scientists have searched for the origins of ancient sea-going reptiles from the Age of Dinosaurs. Now a team of Swedish and Norwegian palaeontologists has discovered remains of the earliest known ichthyosaur or ‘fish-lizard’ on the remote Arctic island of Spitsbergen.
Overweight and obesity among four-year-olds increased during the COVID-19 pandemic, according to a new study by Uppsala University involving over 200,000 children in Sweden. The number of children with obesity increased by some 30 percent, and there are large regional differences. The study was published in the journal Acta Paediatrica.
Detailed images of illness, death and cancelled activities; these were some of the common themes of children’s drawings during the COVID-19 pandemic. A new study from Uppsala University, in which researchers studied 91 drawings made by children aged between 4 and 6, shows that the pandemic affected the children significantly and that they had extensive knowledge about the disease.
A research group at Uppsala University has developed a simple and effective artificial blood-brain barrier model that can be used to determine how well antibody-based therapies can enter the brain. Today animal experimentation is the most common method for testing an antibody’s function and the new model could reduce the need for animal testing.
The use of broad-spectrum antibiotics increased drastically in intensive care at the beginning of the Covid-19 pandemic. At first, this helped patients and seemed to prevent the growth of most bacteria. However, it also contributed to a sharp growth in enterococci, an antibiotic-tolerant group of bacteria, which rendered the treatment of urinary tract infections more difficult.
Thanks to a new prognostic method for detecting cancers including cancer of the large intestine, doctors could provide clearer disease prognoses and predict which patients will respond best to immunotherapy. The method consists of a combination of two types of immune cells that characterise certain forms of cancer. This has been shown in a new study published in the journal eBioMedicine.
The earlier infants begin to taste small samples of solid food, the earlier they eat more food and stop breastfeeding. This is shown in a new study from Uppsala University and Sophiahemmet University, in which the mothers of 1,251 infants from all over Sweden participated. Almost half of the infants received tastings at the age of four months.